%0 Journal Article
%T Development of a fluid
%A Ali Dehghani
%A Ali Tavakoli Golpaygani
%A Alireza Karimi
%A Daniel M. Espino
%A Hamed Abdi
%A Kamran Hassani
%J Perfusion
%@ 1477-111X
%D 2019
%R 10.1177/0267659118811045
%X Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5£¿mm between the anterior and posterior leaflets. The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0£¿mm. However, MR increased this blood flow, with increases in the velocity and pressure within the atrium. However, the pressure within the aorta did not vary meaningfully (ranging from 22£¿kPa for a ¡®healthy¡¯ model to 25£¿kPa for severe MR). The findings from this study have implications not only for understanding the changes in pressure and velocity as a result of MR in the ventricle, atrium or aorta, but also for the development of a computational model suitable for clinical translation when diagnosing and determining treatment for MR
%K blood flow
%K fluid-structure interaction
%K left atrium
%K left ventricle
%K mitral regurgitation
%U https://journals.sagepub.com/doi/full/10.1177/0267659118811045