%0 Journal Article
%T The Prognostic Significance of Lymph Node Ratio and Log Odds Ratio in Laryngeal Squamous Cell Carcinoma
%A Feng Yu
%A Guojie Tan
%A Junhao Mai
%A Xinrui Zhang
%A Xuekui Liu
%A Yibo Zhou
%A Zheng Zhao
%J OTO Open
%@ 2473-974X
%D 2018
%R 10.1177/2473974X18792008
%X To investigate whether lymph node ratio (LNR) and log odds ratio (LODDS) have prognostic significance for overall survival (OS) and disease-free survival (DFS) in patients with laryngeal squamous cell cancer (LSCC) treated with curative intent. Case-control study. University hospital. Records of 229 patients with LSCC who underwent surgery with a curative intent with or without adjuvant treatment from 2000 to 2014 were reviewed. The clinicopathological parameters LNR and LODDS were analyzed; univariate and multivariate analysis was performed to evaluate the prognosis of each for OS and DFS. The 5-year OS was 81.7% for LNR ¡Ü0.233 and 47.1% for LNR >0.233, and the 5-year OS was 79.6% for LODDS ¡Ü¨C0.1 and 51.8% for LODDS >¨C0.1, respectively. In the univariate analysis, the independent variables were subsites, pT stage (pT1 and pT2 vs pT3 and pT4), pN, pTNM, alcohol consumption, and LNR and LODDS (P < .05). By multivariate analysis, we determined that subsites, pT stage, alcohol consumption, LNR, and LODDS were independent prognostic predictors of survival (P < .05). Univariate and multivariate models identified that both LNR and LODDS were significant prognostic factors for survival. However, the hazard ratio (HR) for LNR >0.233 vs ¡Ü0.233 was 8.95 (95% confidence interval [CI], 3.18-25.16; P < .001) in OS, and the HR was 11.37 (95% CI, 4.02-32.15; P < .001) in DFS. The risk of LNR was noticeably greater than other factors. LNR and LODDS were both prognostic factors for OS and DFS. However, LNR was confirmed as a more reliable indicator for evaluating the prognosis, and it can be used to increase the prognostic value of the traditional TNM classification of LSCC
%K laryngeal carcinoma
%K squamous cell cancer
%K lymph node ratio
%K neck dissection
%U https://journals.sagepub.com/doi/full/10.1177/2473974X18792008