%0 Journal Article
%T The angiotensin II type 1 receptor blocker azilsartan can overwhelm the sympathetic nerve activation stimulated by coadministration of calcium channel blockers
%A Junichiro Hayano
%A Ken Kiyono
%A Masashi Mizuno
%A Michio Fukuda
%A Minamo Ono
%A Nobuyuki Ohte
%A Ryo Sato
%A Toshiyuki Miura
%A Yoshiharu Yamamoto
%A Yukako Isobe-Sasaki
%J Journal of the Renin
%@ 1752-8976
%D 2019
%R 10.1177/1470320319839525
%X In our recent study, non-Gaussianity of heart rate variability (¦Ë25s), an indicator of sympathetic nerve activity, did not change during two-day treatment with the angiotensin II type 1 receptor blocker (ARB) azilsartan. Coadministration of calcium channel blockers (CCBs) might affect the study results. In this subanalysis, 20 patients with chronic kidney disease (14 men; age 61¡À15 years) were divided into three groups: patients with coadministration of L-type CCB, patients without coadministration of CCB, and patients with coadministration of sympathoinhibitory (L/T- or L/T/N-type) CCB. ¦Ë25s was calculated separately in daytime and nighttime. Daytime ¦Ë25s at baseline was higher in patients with L-type CCB coadministration (0.62¡À0.18, n = 5) compared with those without CCB (0.49¡À0.13, n = 11) and those with sympathoinhibitory CCB (0.46¡À0.06, n = 4). The relationship between the changes in daytime ¦Ë25s and systolic blood pressure was positive in patients with L-type CCB coadministration, whereas the relationship was inverse in the other two groups. A larger decrease in daytime ¦Ë25s was shown in patients with L-type CCB coadministration compared with those in the other two groups. CCBs, as well as diuretics, are recommended as second-line antihypertensive agents. Our results suggested that ARBs can overwhelm the activation of sympathetic nerve activity stimulated by coadministration of L-type CCBs
%K Angiotensin receptor blocker
%K calcium channel blocker
%K chronic kidney disease
%K heart rate variability
%K sympathetic nerve activity
%U https://journals.sagepub.com/doi/full/10.1177/1470320319839525