%0 Journal Article
%T Effect of Open
%A Damianos G. Kokkinidis
%A Giuseppe Lanzino
%A Pavlos Texakalidis
%A Stefanos Giannopoulos
%J Journal of Endovascular Therapy
%@ 1545-1550
%D 2018
%R 10.1177/1526602818783505
%X Purpose:To compare periprocedural complications and in-stent restenosis rates associated with open- vs closed-cell stent designs used in carotid artery stenting (CAS). Methods: A systematic search was conducted to identify all randomized and observational studies published in English up to October 31, 2017, that compared open- vs closed-cell stent designs in CAS. Identified studies were included if they reported the following outcomes: stroke, transient ischemic attack (TIA), myocardial infarction (MI), hemodynamic depression, new ischemic lesions detected on imaging, and death within 30 days, as well as the incidence of in-stent restenosis. A random-effects model meta-analysis was employed. Model results are reported as the odds ratio (OR) and 95% confidence interval (CI). The I2 statistic was used to assess heterogeneity. Results: Thirty-three studies (2 randomized trials) comprising 20, 291 patients (mean age 71.3¡À3.0 years; 74.6% men) were included. Patients in the open-cell stent group had a statistically significant lower risk of restenosis £¿40% (OR 0.42, 95% CI 0.19 to 0.92; I2=0%) and £¿70% (OR 0.23, 95% CI 0.10 to 0.52; I2=0%) at a mean follow-up of 24 months. No statistically significant differences were identified for periprocedural stroke, TIA, new ischemic lesions, MI, hemodynamic depression, or death within 30 days after CAS. Sensitivity analysis of the 2 randomized controlled trials only did not point to any significant differences either. Conclusion: Use of open-cell stent design in CAS is associated with a decreased risk for restenosis when compared to the closed-cell stent, without significant differences in periprocedural outcomes
%K carotid artery stenting
%K closed-cell design
%K complications
%K in-stent restenosis
%K mortality
%K open-cell design
%K stenosis
%K stent
%K stroke
%U https://journals.sagepub.com/doi/full/10.1177/1526602818783505