%0 Journal Article
%T The Ethics of Health Care Delivery in a Pediatric Malaria Vaccine Trial: The Perspectives of Stakeholders From Ghana and Tanzania
%A Bernice Elger
%A Claire Leonie Ward
%A David Shaw
%A Evelyn Anane-Sarpong
%A Marcel Tanner
%A Osman Sankoh
%J Journal of Empirical Research on Human Research Ethics
%@ 1556-2654
%D 2018
%R 10.1177/1556264617742236
%X This study explores ethical issues raised in providing medical care to participants and communities of low-resource settings involved in a Phase II/III pediatric malaria vaccine trial (PMVT). We conducted 52 key informant interviews with major stakeholders of an international multi-center PMVT (GSK/PATH-MVI RTS,S) (NCT00866619) in Ghana and Tanzania. Based on their stakeholder experiences, the responses fell into three main themes: (a) undue inducement, (b) community disparities, and (c) broad therapeutic misconceptions. The study identified the critical ethical aspects, from the perspectives of stakeholders, of delivering health care during a PMVT. The study showed that integrating research into health care services needs to be addressed in a manner that upholds the favorable risk¨Cbenefit ratio of research and attends to the health needs of local populations. The implementation of research should aim to improve local standards of care through building a collaborative agenda with local institutions and systems of health
%K ethics
%K vaccines
%K therapeutic misconception
%K undue inducement
%K disparity
%U https://journals.sagepub.com/doi/full/10.1177/1556264617742236