%0 Journal Article %T Serum interleukin 6 and cancer antigen 125 in the non %A Chongdee Dangrat %A Prasong Tanmahasamut %A Ratthiporn Preukthanathorn %J Journal of Endometriosis and Pelvic Pain Disorders %@ 2284-0273 %D 2018 %R 10.1177/2284026518779861 %X The role of interleukin 6 in endometriosis has been extensively studied but results were inconsistent. The purpose of this study was to determine the performance of serum interleukin 6 and serum cancer antigen 125 for non-invasive diagnosis of endometriosis. In this prospective diagnostic study, 100 reproductive women who underwent laparoscopy were studies. Patients were divided into endometriosis group (n£¿=£¿60) and control group (n£¿=£¿40). Blood samples were taken preoperatively for analysis of serum interleukin 6 and cancer antigen 125 levels. Level of serum interleukin 6 and cancer antigen 125 in endometriosis group were significantly higher than those in control group (1.93 versus <1.50£¿pg/mL and 41.85 versus 11.86£¿IU/mL, respectively). A cutoff level of interleukin 6 at 1.52£¿pg/mL provided sensitivity of 63.3%, specificity of 55%, positive predictive value of 67.9%, and negative predictive value of 50%. The threshold level of cancer antigen 125 at 31 IU/mL had sensitivity of 70%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 69%. The combined test had sensitivity of 86.7%, specificity of 60%, positive predictive value of 76.5%, and negative predictive value of 75%. The area under receiver operating characteristic curve of serum interleukin 6, cancer antigen 125, and combined test were 0.614, 0.945, and 0.945, respectively. Serum interleukin 6 is not suitable to be a candidate of serum marker for the diagnosis of endometriosis. Serum cancer antigen 125 is better than interleukin 6 for detection of endometriosis stage III/IV. Both of them had low performance for diagnostic test in minimal to mild endometriosis. The combined test does not add more benefit than using cancer antigen 125 alone %K Endometriosis %K interleukin 6 %K cancer antigen 125 %K non-invasive %K diagnosis %U https://journals.sagepub.com/doi/full/10.1177/2284026518779861