%0 Journal Article
%T Small Leucine
%A Andrea Janicova
%A Heiko Roedig
%A Liliana Schaefer
%A Louise Tzung-Harn Hsieh
%A Madalina V. Nastase
%A Malgorzata Wygrecka
%J Journal of Histochemistry & Cytochemistry
%@ 1551-5044
%D 2018
%R 10.1369/0022155417738752
%X It is now well-established that members of the small leucine-rich proteoglycan (SLRP) family act in their soluble form, released proteolytically from the extracellular matrix (ECM), as danger-associated molecular patterns (DAMPs). By interacting with Toll-like receptors (TLRs) and the inflammasome, the two SLRPs, biglycan and decorin, autonomously trigger sterile inflammation. Recent data indicate that these SLRPs, besides their conventional role as pro-inflammatory DAMPs, additionally trigger anti-inflammatory signaling pathways to tightly control inflammation. This is brought about by selective employment of TLRs, their co-receptors, various adaptor molecules, and through crosstalk between SLRP-, reactive oxygen species (ROS)-, and sphingolipid-signaling. In this review, the complexity of SLRP signaling in immune and kidney resident cells and its relevance for renal inflammation is discussed. We propose that the dichotomy in SLRP signaling (pro- and anti-inflammatory) allows for fine-tuning the inflammatory response, which is decisive for the outcome of inflammatory kidney diseases
%K autophagy
%K biglycan
%K decorin
%K extracellular matrix
%K fibrosis
%K inflammasome
%K inflammation
%K innate immunity
%K sphingosine kinase
%K TGF-¦Â
%K Toll-like receptor
%U https://journals.sagepub.com/doi/full/10.1369/0022155417738752