%0 Journal Article
%T Intracellular Ca2+ Release and Synaptic Plasticity: A Tale of Many Stores
%A Nigel J. Emptage
%A William J. Foster
%A Zahid Padamsey
%J The Neuroscientist
%@ 1089-4098
%D 2019
%R 10.1177/1073858418785334
%X Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores: the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses
%K synaptic plasticity
%K endoplasmic reticulum
%K mitochondria
%K lysosomes
%K Ca2+ stores
%K hippocampus
%K LTP
%K LTD
%K acidic stores
%K Ca2+ signaling
%U https://journals.sagepub.com/doi/full/10.1177/1073858418785334