%0 Journal Article
%T A retrospective clinical audit of general practices in Australia to determine the motivation for switch to dolutegravir/abacavir/lamivudine and clinical outcomes
%A Dannae Brown
%A David Baker
%A David Orth
%A Fraser Drummond
%A Ken Koh
%A Mark Bloch
%A Norman Roth
%A Pedro E Ferrer
%A Rimgaile Urbaityte
%A Robert Finlayson
%J International Journal of STD & AIDS
%@ 1758-1052
%D 2018
%R 10.1177/0956462417730474
%X The most common reasons for switching HIV-1 therapy in patients with virologic suppression are treatment regimen simplification and resolving tolerability issues. Single-pill regimens that include an integrase inhibitor are recommended options. A retrospective clinical audit was performed to determine the motivations for switching to dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC) at high HIV-caseload general practice clinics in Australia. The most common reasons for switching from a prior suppressive therapy to DTG/ABC/3TC were simplification of regimen, resolving toxicity/intolerance and patient preference (73%, 13% and 12%, respectively). Kaplan¨CMeier analysis showed that the probability of patients remaining on DTG/ABC/3TC therapy at 12 months was 95.1%. Switching to DTG/ABC/3TC from a range of other regimens was associated with a discontinuation rate of 3.2%, with 2.5% of patients discontinuing due to adverse events and no patients discontinuing due to virologic failure. Switching to DTG/ABC/3TC was a viable treatment strategy in this cohort of Australian patients
%K Dolutegravir
%K HIV
%K switch
%K real world
%U https://journals.sagepub.com/doi/full/10.1177/0956462417730474