%0 Journal Article
%T A randomised controlled trial exploring the effects of different beverages consumed alongside a nitrate
%A Andrew M Jones
%A Anni Vanhatalo
%A Lee J Wylie
%A Paul T Morgan
%A Sinead TJ McDonagh
%J Nutrition and Health
%@ 2047-945X
%D 2018
%R 10.1177/0260106018790428
%X Ingestion of nitrate (NO3-)-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP). However, the pharmacokinetic response to the combined ingestion of NO3- and polyphenol-rich or low polyphenol alcoholic beverages is unknown. The aim of this study was to investigate how the consumption of low and high polyphenolic alcoholic beverages combined with a NO3--rich meal can influence NO3- metabolism and systemic BP. In a randomised, crossover trial, 12 normotensive males (age 25 ¡À 5 years) ingested an acute dose of NO3- (¡«6.05 mmol) in the form of a green leafy salad, in combination with either a polyphenol-rich red wine (NIT-RW), a low polyphenol alcoholic beverage (vodka; NIT-A) or water (NIT-CON). Participants also consumed a low NO3- salad and water as a control (CON; ¡«0.69 mmol NO3-). BP and plasma, salivary and urinary [NO3-] and nitrite ([NO2-]) were determined before and up to 5 h post ingestion. Each NO3--rich condition elevated nitric oxide (NO) biomarkers when compared with CON (P < 0.05). The peak rise in plasma [NO2-] occurred 1 h after NIT-RW (292 ¡À 210 nM) and 2 h after NIT-A (318 ¡À 186 nM) and NIT-CON (367 ¡À 179 nM). Systolic BP was reduced 2 h post consumption of NIT-RW (-4 mmHg), NIT-A (-3 mmHg) and NIT-CON (-2 mmHg) compared with CON (P < 0.05). Diastolic BP and mean arterial pressure were also lower in NIT-RW and NIT-A compared with NIT-CON (P < 0.05). A NO3--rich meal, consumed with or without an alcoholic beverage, increases plasma [NO2-] and lowers systemic BP for 2¨C3 h post ingestion
%K Alcohol
%K blood pressure
%K dietary nitrate
%K Mediterranean diet
%K nitric oxide
%K pharmacokinetics
%K red wine
%U https://journals.sagepub.com/doi/full/10.1177/0260106018790428