%0 Journal Article
%T Prediction of high
%A Jun Matsubayashi
%A Katsutoshi Sugimoto
%A Kazuhiro Saito
%A Koichi Tokuuye
%A Taiyo L Harada
%A Toshitaka Nagao
%A Yoichi Araki
%J Acta Radiologica
%@ 1600-0455
%D 2018
%R 10.1177/0284185117725778
%X Recently, diffusion-weighted imaging (DWI) and quantitative enhancement ratio measured at the hepatobiliary phase (HBP) of Gd-EOB-DTPA¨Cenhanced magnetic resonance imaging (MRI) has been established as an effective method for evaluating liver fibrosis. To evaluate which is a more favorable surrogate marker in predicting high-stage liver fibrosis, apparently diffusion coefficient (ADC) value or quantitative enhancement ratio measured on HBP. Eighty-three patients with 99 surgically resected hepatic lesions were enrolled in this study. DWI was performed with b-values of 100 and 800£¿s/mm2. Regions of interest were set on ADC map, and the HBP of Gd-EOB-DTPA¨Cenhanced MRI, to calculate ADC value, liver-to-muscle ratio (LMR), liver-to-spleen ratio (LSR), and contrast enhancement index (CEI) of liver. We compared these parameters between low-stage fibrosis (F0, F1, and F2) and high-stage fibrosis (F3 and F4). Receiver operating characteristic analysis was performed to compare the diagnostic performance when distinguishing low-stage fibrosis from high-stage fibrosis. LMR and CEI were significantly lower at high-stage fibrosis than at the low stage (P£¿<£¿0.01 and P£¿=£¿0.04, respectively), whereas LSR did not show a significant difference (P£¿=£¿0.053). No significant difference was observed in diagnostic performance between LMR and CEI (P£¿=£¿0.185). The best sensitivity and specificity, when an LMR of 2.80 or higher was considered to be low-stage fibrosis, were 82.4% and 75.6%, respectively. ADC value showed no significant differences among fibrosis grades (P£¿=£¿0.320). LMR and CEI were both adequate surrogate parameters to distinguish high-stage fibrosis from low-stage fibrosis
%K Liver fibrosis
%K diffusion-weighted imaging (DWI)
%K magnetic resonance imaging (MRI)
%K Gd-EOB-DTPA
%K enhancement ratio
%K hepatosteatosis
%U https://journals.sagepub.com/doi/full/10.1177/0284185117725778