%0 Journal Article
%T Safety profile of gadoxetate disodium in elderly patients (≡65 years)
%A Carsten Schwenke
%A Jan Endrikat
%A Josy Breuer
%A Kai Vogtlaender
%A Susan Dohannish
%J Acta Radiologica
%@ 1600-0455
%D 2018
%R 10.1177/0284185117700673
%X Safety data on routine clinical use of gadoxetate disodium in elderly patients is not reported yet. To assess the safety of liver specific gadoxetate disodium in contrast enhanced magnetic resonance imaging in elderly patients (≡65 years) in comparison to adults (18每64 years). Safety data on gadoxetate disodium were analyzed from 12 clinical phase II每III studies and from our pharmacovigilance database. A comparison between elderly (≡65 years) versus adults (18每64 years) was performed with respect to the frequency of drug-related adverse events (AEs) in clinical phase II每III studies and adverse drug reactions (ADRs) in the pharmacovigilance database. In clinical studies, 1989 patients were enrolled: 675 elderly and 1314 adults. Twenty-three elderly patients (3.4%) suffered at least one drug-related AE in contrast to 58 patients (4.4%) in the group of adults (odds ratioˋ=ˋ0.76; 95% confidence intervalˋ=ˋ0.45每1.27). Since marketing authorization in 2004, more than 3.5 million patients have been exposed to gadoxetate disodium worldwide: 1.7 million (48.6%) in elderly and 1.8 million (51.4%) in adults. The number of patients with post-marketing ADRs (total nˋ=ˋ793) was 354 (0.021%) in the elderly group and 439 (0.024%) in the adult group. Thus, there were significantly fewer patients with ADRs reported in the group of elderly versus adults (Pˋ=ˋ0.028). Hypersensitivity/immune system disorders, gastrointestinal disorders, and respiratory disorders were the most frequent ADRs in both groups, elderly and adults. The incidence of drug-related AEs in clinical studies was similar and that of patients with ADRs in the post-marketing setting was lower in elderly (≡65 years) compared with younger adults aged 18每64 years. Overall, gadoxetate disodium shows a favorable safety profile in both age groups
%K Gadoxetate disodium
%K safety
%K elderly
%U https://journals.sagepub.com/doi/full/10.1177/0284185117700673