%0 Journal Article
%T Correlation between hypoxic area in primary brain tumors and WHO grade: differentiation from malignancy using 18F
%A Jun Hatazawa
%A Kaori Sakurada
%A Kazukuni Kirii
%A Kenichiro Matsuda
%A Masafumi Kanoto
%A Takaaki Hosoya
%A Toshitada Hiraka
%A Yukihiko Sonoda
%A Yukio Sugai
%A Yuuki Toyoguchi
%J Acta Radiologica
%@ 1600-0455
%D 2018
%R 10.1177/0284185117711474
%X 18F-fluoromisonidazole positron emission tomography (FMISO-PET) has been used for identification of hypoxic areas in tumors, and since hypoxia causes hypoxia-inducible factor-1 and enhancement of tumor growth, identifying the hypoxic area in the tumor tissue is important. To evaluate the usefulness of FMISO-PET in the grading of primary brain tumors. FMISO-PET was performed preoperatively on 41 consecutive patients with pathologically confirmed brain tumor. A neuroradiologist retrospectively measured both maximum standardized uptake value (SUVmax) and mean SUV (SUVmean) in the tumor and normal cerebellar parenchyma. Maximum tumor/normal control ratio (T/Nmax) and mean tumor/normal control ratio (T/Nmean) were calculated and analyzed. There was a positive correlation between World Health Organization (WHO) grade and both T/Nmax and T/Nmean (r£¿=£¿0.731 and 0.713, respectively). When all cases were divided into benign (WHO grade II) and malignant groups (III and IV), there were significant differences between the two groups in both T/Nmax and T/Nmean (P£¿<£¿0.001). If the cutoff value was defined as T/Nmax£¿=£¿1.25 and T/Nmean£¿=£¿1.23, T/Nmax had a sensitivity of 90.0% and a specificity of 90.9% while T/Nmean had a sensitivity of 93.3% and a specificity of 90.9% in differentiating the benign group from the malignant group. Both T/Nmax and T/Nmean in FMISO-PET have a positive correlation with primary brain tumor grading, making FMISO-PET useful in diagnosing the malignancy of primary brain tumors
%K Malignant glioma
%K fluoromisonidazole
%K WHO grade
%K PET-CT
%U https://journals.sagepub.com/doi/full/10.1177/0284185117711474