%0 Journal Article
%T Copeptin and insulin
%A Anna Norhammar
%A Kerstin Brismar
%A Linda G Mellbin
%A Maria Isabel Sm¨¢rad¨®ttir
%A Sergiu-Bogdan Catrina
%A Viveca Gyberg
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118804451
%X Copeptin and insulin-like growth factor binding protein-1 analysed at admission for a myocardial infarction in patients with type 2 diabetes mellitus predicts cardiovascular events. The present aim was to study the association between copeptin and insulin-like growth factor binding protein-1, the development of the levels over time, and if the predictive value remained when measured at hospital discharge and 3£¿months thereafter. Copeptin and insulin-like growth factor binding protein-1 were analysed in patients (median age£¿=£¿70, male£¿=£¿68%) with type 2 diabetes mellitus£¿+£¿myocardial infarction at admission (n£¿=£¿393), discharge (n£¿=£¿309) and 3£¿months later (n£¿=£¿288). The primary endpoint was cardiovascular event (cardiovascular death/non-fatal myocardial infarction/stroke) with the three time points as separate baselines. The median copeptin levels were 21.8£¿pmol/L at admission, 8.5£¿pmol/L at discharge and 8.4£¿pmol/L after 3£¿months, while insulin-like growth factor binding protein-1 levels continued to increase. There were significant correlations between the biomarkers at all occasions. During an average follow-up of 2.5£¿years, copeptin, but not insulin-like growth factor binding protein-1, predicted cardiovascular event at all occasions in unadjusted analyses. Copeptin remained as a predictor at discharge and after 3£¿months in the final multiple model (including: heart failure/age/creatinine clearance). The relationship between copeptin and insulin-like growth factor binding protein-1 during the initial phase of a myocardial infarction persisted in a less-stressful situation, and copeptin remained as a prognostic indicator at discharge and 3£¿months later
%K Copeptin
%K vasopressin
%K biomarkers
%K myocardial infarction
%K type 2 diabetes mellitus
%U https://journals.sagepub.com/doi/full/10.1177/1479164118804451