%0 Journal Article
%T Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes
%A Allan Linneberg
%A Daniel R Witte
%A Henrik Vestergaard
%A Line Engelbrechtsen
%A Louise Lundby-Christensen
%A Marit E Jorgensen
%A Niels Grarup
%A Oluf Pedersen
%A Thea Skaaby
%A Theresia M Schnurr
%A Thomas Drivsholm
%A Torben Hansen
%A Vincent E Appel
%A null
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118810365
%X The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes. In total, 12 genetic risk scores for blood pressure, blood lipids and glycaemic traits were constructed. The genetic risk scores were tested for association with carotid intima-media thickness and plaques in patients with type 2 diabetes (n£¿=£¿401) and in non-diabetic individuals (n£¿=£¿648) and for association with glucose levels in two population-based cohorts (n£¿=£¿1328 and n£¿=£¿6161). In patients with type 2 diabetes, the genetic risk scores for pulse pressure were positively associated with plaque formation (¦Â£¿=£¿0.036£¿¡À£¿0.01 standard deviation/allele, p£¿=£¿0.003). The genetic risk score for diastolic blood pressure was negatively associated with carotid intima-media thickness (¦Â£¿=£¿¨C0.037£¿¡À£¿0.01 standard deviation/allele, p£¿=£¿0.005), although not significant after correction for multiple testing (p£¿<£¿0.0042). In a meta-analysis of individuals with and without type 2 diabetes, the high-density lipoprotein genetic risk scores showed a trend towards an inverse association with carotid intima-media thickness and plaques, while the low-density lipoprotein genetic risk scores showed a trend towards a positive association with plaque formation but did reach the statistical threshold. Genetic loci for pulse pressure are associated with plaque formation among patients with type 2 diabetes, suggesting an underlying genetic contribution to arterial stiffening and atherosclerosis
%K Type 2 diabetes
%K carotid thickening
%K atherosclerosis
%K risk factors
%K genetic risk score
%U https://journals.sagepub.com/doi/full/10.1177/1479164118810365