%0 Journal Article
%T Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
%A Ana Mercedes Cavaleiro
%A Arnaldo Moura Neto
%A Daniele Pereira Santos-Bezerra
%A Elizabeth Joao Pavin
%A Marcia Nery
%A Marcia Silva Queiroz
%A Maria Beatriz Monteiro
%A Maria Candida Parisi
%A Maria Lucia Correa-Giannella
%A Ricardo Vesoni Perez
%A Sharon Nina Admoni
%A Thiago Andrade Patente
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118820641
%X Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27¨C42] years old; diabetes duration: 21 [15¨C27] years; HbA1c: 8.3% [7.4¨C9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio£¿=£¿0.39; 95% confidence interval£¿=£¿0.17¨C0.90; p£¿=£¿0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes
%K Cardiovascular autonomic neuropathy
%K oxidative stress
%K type 1 diabetes
%K glutathione peroxidase 4
%U https://journals.sagepub.com/doi/full/10.1177/1479164118820641