%0 Journal Article
%T Effects of exercise training on inflammasome
%A Hani Zaidi
%A Harald Arnesen
%A Ida U Njerve
%A Ingebj£¿rg Seljeflot
%A Rune Byrkjeland
%A Sissel £¿kra
%A Svein Solheim
%A Trine B Opstad
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164119836922
%X Adipose tissue produces pro-inflammatory mediators involved in the atherosclerotic process. We investigated whether 12-month exercise training in patients with type 2 diabetes mellitus and coronary artery disease would reduce circulating levels and genetic expression of mediators in the interleukin-18, Caspase-1 and NLR pyrin domain containing 3 pathways. Correlations to glucometabolic variables; fasting glucose, HbA1c, duration of diabetes, insulin, C-peptide, insulin resistance (measured by homeostatic model assessment indexes ¨C insulin resistance) and body mass index at baseline were further assessed. 137 patients (aged 41¨C81£¿years, 17.2% female participants) were included and randomized to a 12-month exercise programme or to a control group. Fasting blood and adipose tissue samples were taken at inclusion and after 12£¿months. No statistically significant difference in changes of any variable between the intervention and the control group was found. At baseline, a positive correlation between insulin and homeostatic model assessment indexes ¨C insulin resistance, interleukin-18 expression in adipose tissue and an inverse correlation between some glucometabolic variables and leukocyte expression of NLR pyrin domain containing 3 and Caspase-1 were observed. No significant effects of long-term exercise training were observed on the inflammasome-related mediators in our patients with combined coronary artery disease and type 2 diabetes mellitus. The observed correlations may indicate a pro-inflammatory state in adipose tissue by overweight and a compensatory downregulation of these mediators in circulating leucocytes
%K Interleukin-18 pathway
%K adipose tissue
%K inflammation
%K coronary artery disease
%K type 2 diabetes
%K exercise training
%U https://journals.sagepub.com/doi/full/10.1177/1479164119836922