%0 Journal Article
%T Predictive Value of Oxidized Low
%A Giovanna D¡¯Andrea
%A Giovanni Gaeta
%A Giuseppe Di Girolamo
%A Luigi Iannaccone
%A Luis R. Lopez
%A Maurizio Maraglione
%A Paul R. J. Ames
%J Clinical and Applied Thrombosis/Hemostasis
%@ 1938-2723
%D 2018
%R 10.1177/1076029618767752
%X Lipid oxidation is a definite feature of atherosclerosis, and oxidized low-density lipoprotein (oxLDL) is not only highly immunogenic but toxic to several cell types. Beta-2-glycoprotein-I (¦Â2GPI) dampens oxLDL toxicity by forming binary oxLDL/¦Â2GPI complexes. We evaluated whether circulating oxLDL/¦Â2GPI complexes are associated to atherosclerosis-related events (ARE) and to venous thromboembolism (VTE). In a cross-sectional case¨Ccontrol study, cases were (a) 57 consecutive patients (male/female [M/F] 33/24, mean age 57 [10] years) attending a thrombosis unit for ARE (myocardial infarction [MI] n = 20, peripheral vascular disease n = 7, and ischemic strokes n = 30); (b) 52 consecutive patients (M/F 22/30, mean age 55 [17] years) attending the same unit for unprovoked (VTE); (c) normal controls comprised 90 participants (M/F 35/55, mean age 41 [15] years); and (d) oxLDL/¦Â2GPI complexes were measured by immunoassay and resulting levels divided into quartiles. The odds ratio (OR) of ARE was greater in the fourth and second quartiles than in the first quartile (8.5 and 6.0, respectively); the OR of developing MI was greatest in the fourth quartile (17.8). By multivariable analysis with age, sex, smoking, lipid status, statin, and ARE phenotypes as independent variables and oxLDL/¦Â2GPI as the dependent variable, only MI predicted oxLDL/¦Â2GPI (P < .0001). OxLDL/¦Â2GPI may be regarded as a marker of ARE, in particular of MI
%K oxidized low-density lipoprotein/¦Â2-glycoprotein-I
%K thrombosis
%K atherosclerosis
%U https://journals.sagepub.com/doi/full/10.1177/1076029618767752