%0 Journal Article
%T Transient power elevation during iron dextran infusion in a patient with a continuous
%A J Brad Williams
%A Kiyotaka Fukamachi
%A Marinela Kreiss
%A Miriam Jacob
%A Nader Moazami
%A Nicole Byram
%A Paulino A Alvarez
%J The International Journal of Artificial Organs
%@ 1724-6040
%D 2019
%R 10.1177/0391398818818565
%X Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. We subsequently studied the effects of iron dextran infusion in an in vitro LVAD mock circulatory loop. The observed increase in flow and power was most likely due to drug¨Cpatient interaction rather than drug¨CLVAD interaction. Mock loops and in vivo animal models may be necessary for proactive evaluation of the safety of intravenous (IV) preparations in this patient population
%K Iron dextran
%K left ventricular assist device
%K pharmacotherapy
%U https://journals.sagepub.com/doi/full/10.1177/0391398818818565