%0 Journal Article
%T Erythropoietin/aloe vera
%A Ahmad Vaez
%A Mahdi Naseri-Nosar
%A Mahmoud Azami
%A Majid Salehi
%A Roksana Tajerian
%A Saeed Farzamfar
%J Journal of Bioactive and Compatible Polymers
%@ 1530-8030
%D 2018
%R 10.1177/0883911517731793
%X This study aimed to develop a recombinant human erythropoietin/aloe vera gel每releasing polyvinyl alcohol/chitosan wound dressing by wet-electrospinning method and investigate the synergistic effects of erythropoietin and aloe vera gel on the excisional wound healing. The polyvinyl alcohol/chitosan (4:1 (w/w)) solution was electrospun into an aloe vera gel每containing water coagulation bath and then coated with the recombinant human erythropoietin每loaded chitosan nanoparticles prepared via ionic gelation technique. The developed sponge-like film was able to release the erythropoietin and aloe vera gel for at least 7 and 1ˋdays, respectively. The dressing was non-toxic to L929 fibroblastic cell line and non-adherent to the wound bed with the contact angle of 67.93∼ˋ㊣ˋ2.31∼. It also possessed the water-uptake capacity and water vapor transmission rate of 26.40%ˋ㊣ˋ3.37% and 2584.00ˋ㊣ˋ144.67ˋgˋmˋ2, respectively. The in vivo study demonstrated the synergistic wound-healing effects of aloe vera gel and erythropoietin on the full-thickness excisional wounds of Wistar rats. The erythropoietin/aloe vera gel每releasing dressing had significantly (nˋ=ˋ4, pˋ<ˋ0.005) higher wound closure (92.96%ˋ㊣ˋ10.09%) than the sterile gauze (73.89%ˋ㊣ˋ2.61%), as the control group, after 2ˋweeks. The differences observed between the wound closure percentages of the aloe vera gel每releasing dressing (85.93%ˋ㊣ˋ6.46%) and the erythropoietin/aloe vera gel每releasing dressing and control group were not statistically significant
%K Aloe vera
%K chitosan
%K erythropoietin
%K polyvinyl alcohol
%K wet-electrospinning
%K wound dressing
%U https://journals.sagepub.com/doi/full/10.1177/0883911517731793