%0 Journal Article
%T Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On
%A Guo-Hong Yang
%A Ji-Hong Zhao
%A Jing Sun
%A Jun-Xiang Liu
%A Rui-Yi Lu
%A Shao-Bo Chen
%A Wen-Jie Ji
%A Xin Zhou
%A Xin-Lin Liu
%A Ying-Ying Zhang
%A Yong-Qiang Ma
%A Yu-Ming Li
%J Clinical and Applied Thrombosis/Hemostasis
%@ 1938-2723
%D 2018
%R 10.1177/1076029617726600
%X To investigate potential clinical characteristics associated with discordance between platelet vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry (FCM) assay and light transmission aggregometry (LTA) in defining high on-clopidogrel platelet reactivity (HPR) after ST-segment elevation myocardial infarction (STEMI). In this study, platelet responsiveness was measured by the above 2 methods simultaneously on day 1 and on day 6 of STEMI onset in 90 consecutive patients who underwent primary percutaneous coronary intervention. The FCM-derived platelet reactivity index and LTA-derived platelet aggregation rate were both significantly reduced after dual antiplatelet therapy on day 6. Multiple variable-adjusted logistic regression analysis revealed that smoking (odds ratio [OR]: 4.507, 95% confidence interval [CI]: 1.123-18.09, P = .034) and onset-to-admission time (per 1 hour increase, OR: 1.196, 95% CI: 1.023-1.398, P = .025) both were independent predictors for the discordance between the 2 methods. Additionally, improved correlation and concordance was observed in nonsmokers compared with smokers. Our data show that smoking and prolonged onset-to-admission time are associated with discordance between platelet VASP-P and LTA in defining HPR after STEMI, which should be considered when planning personalized antiplatelet therapy
%K platelet responsiveness
%K percutaneous coronary intervention
%K platelet reactivity index
%U https://journals.sagepub.com/doi/full/10.1177/1076029617726600