%0 Journal Article %T The single and synergistic effects of montmorillonite and curcumin %A Mahdi Naseri-Nosar %A Mahmoud Azami %A Majid Salehi %A Saeed Farzamfar %J Journal of Bioactive and Compatible Polymers %@ 1530-8030 %D 2018 %R 10.1177/0883911517724809 %X In this study, the single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto the polylactic acid films were investigated on full-thickness excisional wounds of rats . The polylactic acid microfibrillated film was electrospun from a 10% (w/v) polylactic acid in chloroform solution. The curcumin-loaded chitosan microparticles were prepared via ionic gelation technique with high drug loading and encapsulation efficiency. The alkaline-treated polylactic acid films were assembled with positively charged chitosan as the first layer and the negatively charged montmorillonite (NC dressing), curcumin-loaded chitosan microparticles (CCM dressing), and their mixture (1:1 (v/v); NC/CCM dressing) as the second layer via layer-by-layer self-assembly technique. The montmorillonite incorporation increased the hydrophobicity and water vapor transmission rate of the CCM dressing but decreased its water-uptake capacity. The films showed good cytocompatibility to L929 fibroblastic cell line, and the in vivo wound-closure percentage result showed that CCM£¿>£¿NC£¿>£¿NC/CCM£¿>£¿sterile gauze. The overall result indicated that the montmorillonite and curcumin-loaded chitosan microparticles had no considerable positive synergistic effects onwound-healing %K Montmorillonite %K curcumin %K chitosan microparticle %K polylactic acid %K layer-by-layer self-assembly %K skin wound-dressing %U https://journals.sagepub.com/doi/full/10.1177/0883911517724809