%0 Journal Article
%T Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood
%A Hiroki Handa
%A Kazunobu Hara
%A Masashi Tagaya
%A Saki Nagoshi
%A Shinya Okano
%A Shunsuke Takahashi
%A Takuo Murataka
%J The International Journal of Artificial Organs
%@ 1724-6040
%D 2019
%R 10.1177/0391398818815480
%X Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter. Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5£¿min, antithrombin activity every 40£¿min, and thrombin¨Cantithrombin complex every 40£¿min, for a total of 240£¿min of recirculation. The mean time required for the pressure at the inlet of the hemofilter to increase sharply was longer in BPCA-coated than in non-coated hemofilters (66£¿¡À£¿11£¿min vs 25£¿¡À£¿9£¿min, p£¿<£¿0.01). The mean antithrombin activity value at 200 and 240£¿min of recirculation was significantly higher in the experiments with BPCA-coated versus non-coated hemofilters (43.3£¿¡À£¿2.87 vs 33.3£¿¡À£¿5.74, p£¿=£¿0.04; 42.8£¿¡À£¿3.59 vs 31.0£¿¡À£¿5.35, p£¿=£¿0.01, respectively); the antithrombin activity values at the other time points were not significantly different. Furthermore, all thrombin¨Cantithrombin complex values in experiments with the BPCA-coated hemofilters achieved overrange at 80£¿min of recirculation, whereas those with the non-coated hemofilter achieved overrange at 40£¿min. This study suggests that BPCA-coated hemofilters can inhibit antithrombin consumption, contributing to antithrombotic effects in extracorporeal circulation circuits
%K Antithrombin
%K cardiopulmonary bypass
%K dialysis
%K hemofilter
%K polymer
%K thrombin¨Cantithrombin complex
%U https://journals.sagepub.com/doi/full/10.1177/0391398818815480