%0 Journal Article
%T Epigenetic and metabolic programming of innate immunity in sepsis
%A Charles E McCall
%A Vidula Vachharajani
%J Innate Immunity
%@ 1753-4267
%D 2019
%R 10.1177/1753425919842320
%X Sepsis, the 10th leading cause of death, is the most expensive condition in the United States. The immune response in sepsis transitions from hyperinflammatory to a hypoinflammatory and immunosuppressive phase; individual variations regarding timing and overlap between hyper- and hypoinflammation exist in a number of patients. While one third of the sepsis-related deaths occur during hyperinflammation, majority of the sepsis-mortality occurs during the hypoinflammatory phase. Currently, no phase-specific molecular-based therapies exist to treat sepsis. Coordinated epigenetic and metabolic perturbations orchestrate this shift from hyper- to hypoinflammation in innate immune cells during sepsis. These epigenetic and metabolic changes during sepsis progression and therapeutic opportunities they pose are described in this review
%K Epigenetic programming
%K hyperinflammation
%K hypoinflammation
%K immunosuppression
%K metabolism
%K sepsis
%K septic shock
%U https://journals.sagepub.com/doi/full/10.1177/1753425919842320