%0 Journal Article
%T Psychiatric Comorbidities Modify the Association Between Childhood ADHD and Risk for Suicidality: A Population
%A Amy L. Weaver
%A Jill M. Killian
%A Kouichi Yoshimasu
%A Robert C. Colligan
%A Robert G. Voigt
%A Slavica K. Katusic
%A William J. Barbaresi
%J Journal of Attention Disorders
%@ 1557-1246
%D 2019
%R 10.1177/1087054717718264
%X Objective: The objective of this study was to evaluate the effect of psychiatric comorbidities on the association between childhood ADHD and suicidality among adults. Method: Subjects were recruited from a population-based birth cohort. Participating adult subjects with childhood ADHD and non-ADHD controls were administered a structured psychiatric interview to assess suicidality and psychiatric comorbidities. Associations were assessed using logistic regression. Results: Compared with controls, ADHD cases were significantly more likely to meet criteria for suicidality. Subjects with childhood ADHD who met criteria for generalized anxiety disorder had a higher than expected risk of suicidality with an observed odds ratio of 10.94 (95% confidence interval [4.97, 24.08]) compared with an expected odds ratio of 4.86, consistent with a synergistic interaction effect. Significant synergistic interactions were also observed for hypomanic episode and substance-related disorders. Conclusion: Childhood ADHD is significantly associated with adult suicidal risk. Comorbidity between ADHD and some psychiatric disorders is associated with a higher suicidal risk than expected
%K ADHD
%K suicidality
%K adults
%K psychiatric comorbidity
%K epidemiology
%U https://journals.sagepub.com/doi/full/10.1177/1087054717718264