%0 Journal Article
%T Effect of 12
%A Anastasios Tentolouris
%A Charalambos Vlachopoulos
%A Dimitrios Tsilingiris
%A Ioanna Eleftheriadou
%A Maria Sykara
%A Nikolaos Tentolouris
%A Pinelopi Grigoropoulou
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118805320
%X Cardiovascular disease is the leading cause of morbidity and mortality in subjects with type 2 diabetes mellitus. Increased aortic stiffness, assessed with the carotid每femoral pulse wave velocity, is an independent risk factor for cardiovascular disease. Statins reduce effectively cardiovascular disease and mortality in high-risk patients. The aim of this prospective non-randomized, observational study was to examine the impact of treatment with either 10ˋmg atorvastatin plus diet or diet alone on carotid每femoral pulse wave velocity in subjects with type 2 diabetes mellitus and dyslipidaemia. A total of 79 subjects with type 2 diabetes mellitus and dyslipidaemia were included; 46 subjects were treated with atorvastatin 10ˋmg daily plus diet and 33 were managed by diet alone for 12ˋmonths. Carotid每femoral pulse wave velocity and carotid每radial pulse wave velocity were measured using applanation tonometry. In the atorvastatin-treated group, carotid每femoral pulse wave velocity reduced significantly during the study and there was a trend for reduction in the carotid每radial pulse wave velocity. Total cholesterol, low-density lipoprotein cholesterol, triglycerides and C-reactive protein were reduced only in the atorvastatin-treated participants. No significant changes were found in body mass index, blood pressure, heart rate, diabetes control and high-density lipoprotein cholesterol in either study group. Treatment with low-dose atorvastatin for 12ˋmonths improves carotid每femoral pulse wave velocity in subjects with type 2 diabetes mellitus and dyslipidaemia
%K Arterial stiffness
%K pulse wave velocity
%K atorvastatin
%K statin
%K type 2 diabetes
%K dyslipidaemia
%U https://journals.sagepub.com/doi/full/10.1177/1479164118805320