%0 Journal Article
%T Intravenous Immunoglobulin for Patients With Alzheimer¡¯s Disease: A Systematic Review and Meta
%A Apostolos Manolopoulos
%A Apostolos Tsapas
%A Dimitrios Kapogiannis
%A Eleni Bekiari
%A Ioannis Avgerinos
%A Konstantinos Malandris
%A Magda Tsolaki
%A Panagiotis Andreadis
%A Thomas Karagiannis
%J American Journal of Alzheimer's Disease & Other Dementias£¿
%@ 1938-2731
%D 2019
%R 10.1177/1533317519843720
%X To assess the efficacy and safety of intravenous immunoglobulin (IVIg) for patients with Alzheimer¡¯s disease (AD). We searched electronic databases and other sources for randomized controlled trials comparing IVIg with placebo or other treatment for adults with AD. Primary outcome was change from baseline in Alzheimer¡¯s Disease Assessment Scale¨CCognitive subscale (ADAS-Cog). Five placebo-controlled trials were included in the meta-analysis. Compared to placebo, IVIg 0.2 and 0.4 g/kg once every two weeks did not change ADAS-Cog score (weighted mean difference: 0.37, 95% confidence interval: £¿1.46 to 2.20 and 0.77, £¿1.34 to 2.88, respectively). Furthermore, except for an increase in the incidence of rash, IVIg did not affect the incidence of other adverse events. IVIg, albeit safe, is inefficacious for treatment of patients with AD. Future trials targeting earlier stages of disease or applying different dosing regimens may be warranted to clarify its therapeutic potential
%K Intravenous immunoglobulin
%K Alzheimer¡¯s disease
%K meta-analysis
%K systematic review
%U https://journals.sagepub.com/doi/full/10.1177/1533317519843720