%0 Journal Article
%T Melodic intonation therapy in post
%A Ana M Haro-Mart¨ªnez
%A Blanca Fuentes
%A Exuperio D¨ªez-Tejedor
%A Genny Lubrini
%A Rosario Madero-Jarabo
%J Clinical Rehabilitation
%@ 1477-0873
%D 2019
%R 10.1177/0269215518791004
%X To collect data to estimate the sample size of a definitive randomized controlled trial to evaluate the effects of Melodic Intonation Therapy in post-stroke nonfluent aphasia. A randomized, crossover, interventional pilot trial. Departments of Neurology and Rehabilitation from a university general hospital. Stroke survivors with post-stroke nonfluent aphasia. Patients randomized to group 1 had treatment with Melodic Intonation Therapy first (12 sessions over six£¿weeks) followed by no treatment; the patients in group 2 started active treatment between three and six£¿months after their inclusion in the study, serving as waiting list controls for the first phase. The Communicative Activity Log (CAL) questionnaire and the Boston Diagnostic Aphasia Examination (BDAE) were evaluated at baseline, and at six and 12£¿weeks. Twenty patients were included. Four of the patients allocated to group 2 crossed over to group 1, receiving the treatment at first. Intention-to-treat analysis: after adjustment for baseline scores, the mean difference in the CAL evaluation from baseline in the treated group was 8.5 points (95% confidence interval (CI), 0.11¨C17.0; P£¿=£¿.043), with no significant change in any of the BDAE sections. Per-protocol analysis showed similar results with a clear treatment effect (P£¿=£¿.043) on the CAL. Melodic Intonation Therapy might have a positive effect on the communication skills of stroke survivors with nonfluent aphasia as measured by the CAL questionnaire. A full-scale trial with at least 27 patients per group is necessary to confirm these results
%K Ischaemic stroke
%K aphasia
%K melodic intonation therapy
%U https://journals.sagepub.com/doi/full/10.1177/0269215518791004