%0 Journal Article
%T Retrospective analysis of effects of sodium
%A Akira Kanamori
%A Atsuko Mokubo
%A Daisuke Suzuki
%A Hareaki Yamamoto
%A Hideo Machimura
%A Hidetoshi Shimura
%A Hiroshi Takeda
%A Hiroyuki Sakai
%A Hisakazu Degawa
%A Kazuo Kobayashi
%A Kazuyoshi Sato
%A Keiichi Chin
%A Kouta Aoyama
%A Masaaki Miyakawa
%A Masahiro Takihata
%A Masao Toyoda
%A Mitsuo Obana
%A Moritsugu Kimura
%A Nobuo Hatori
%A Shinichi Nakajima
%A Shinichi Umezawa
%A Shun Ito
%A Takayuki Furuki
%A Togo Aoyama
%A Tomoya Umezono
%A Toshimasa Hishiki
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118802759
%X The aim of this study was to assess the renal effects of the glucose-lowering SGLT2 inhibitors in Japanese type 2 diabetes mellitus patients with chronic kidney disease. The Kanagawa Physicians Association maintains a registry of patients who visit their 31 clinics. Clinical data of type 2 diabetes mellitus patients with chronic kidney disease, who were prescribed SGLT2 inhibitors in addition to other treatments, were collected and analysed. SGLT2i was associated with a fall in HbA1c from 64.1£¿¡À£¿16.7 mmol/mol (8.0£¿¡À£¿1.5%) to 56.5£¿¡À£¿12.9 mmol/mol (7.3£¿¡À£¿1.2%) (p£¿<£¿0.01) in 869 analysed cases, a decrease in urine albumin-creatinine ratio from a median of 47.1 to 41.1£¿mg/gCr, and decrease in estimated glomerular filtration rate from 77.7£¿¡À£¿23.9 to 75.0£¿¡À£¿23.9£¿mL/min/1.73£¿m2 (p£¿<£¿0.01). The effect on albumin-creatinine ratio was independent of age or stage of estimated glomerular filtration; however, there was a significant negative correlation between albumin-creatinine ratio at the initiation of SGLT2 inhibitor and change in ACR. Multiple linear regression analysis identified use of empagliflozin, ¦Â-blockers, and sulphonylureas, ¦¤systolic blood pressure at office, serum Cr and albumin-creatinine ratio value at initiation of SGLT2 inhibitor as independent and significant determinants of change in ACR. This study confirmed that the beneficial renal effects of SGLT2 inhibitor in Japanese type 2 diabetes mellitus patients with chronic kidney disease, similar to those reported in large-scale clinical trials conducted in Western countries
%K Sodium-glucose co-transporter 2 inhibitor
%K urine albumin-creatinine ratio
%K chronic kidney disease
%K retrospective study
%U https://journals.sagepub.com/doi/full/10.1177/1479164118802759