%0 Journal Article
%T Cardiac ventricular sizes are reduced in patients with long
%A Andreas Fuchs
%A B£¿rge G Nordestgaard
%A Helle Corinth
%A Henrik £¿ Hjortkj£¿r
%A J Tobias K¨¹hl
%A Jannik Hilsted
%A Klaus F Kofoed
%A Lars K£¿ber
%A Per E Sigvardsen
%A Peter Rossing
%A Tonny Jensen
%A Ulrik M Mogensen
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118819961
%X Type 1 diabetes entails increased cardiovascular morbidity and cardiac chamber sizes are associated with cardiovascular disease. The aim of this study was to compare cardiac chamber sizes in normoalbuminuric persons with type 1 diabetes to a background population without diabetes. In a cross-sectional study, we examined 71 normoalbuminuric persons with long-term type 1 diabetes without known cardiovascular disease using cardiac multi-detector computed tomography. Cardiac chamber sizes and left ventricular remodelling were compared to persons without diabetes from the Copenhagen General Population Study. Participants were median (interquartile range) 54 (48¨C60) (type 1 diabetes) and 57 (50¨C64) (without diabetes) years old and 59% were men (both groups). Participants with type 1 diabetes had smaller left ventricular mass (£¿3.5£¿g/m2, 95% confidence interval £¿5.8 to £¿1.3) and left (£¿4.0£¿mL/m2, 95% confidence interval £¿6.9 to £¿1.0) and right (£¿11.7£¿mL/m2, 95% confidence interval £¿15.4 to £¿7.9) ventricular volumes in multivariable analyses (adjusted for age, sex, body composition, blood pressure and antihypertensive medication), but no differences in atrial volumes. Persons with long-term type 1 diabetes had smaller left ventricular mass and biventricular volumes, yet similar atrial sizes, compared to a background population without diabetes. These findings may reflect subclinical development of diabetic cardiomyopathy
%K Cardiac computed tomography
%K type 1 diabetes
%K normoalbuminuria
%K diabetic cardiomyopathy
%K left ventricle
%K right ventricle
%U https://journals.sagepub.com/doi/full/10.1177/1479164118819961