%0 Journal Article
%T Perampanel Pharmacokinetics in Children: Correlation of Dose With Serum Concentrations
%A Andrew J. Gienapp
%A Elizabeth Gaudio
%A James Wheless
%J Journal of Child Neurology
%@ 1708-8283
%D 2019
%R 10.1177/0883073819837465
%X Enzyme-inducing antiseizure drugs taken concomitantly with perampanel are known to influence perampanel serum concentrations. In this study, we examined perampanel dosage, serum concentrations, and the effect of concomitant enzyme-inducing antiseizure drugs in children for a 3-year period. A retrospective chart review determined patient age, weight, perampanel serum concentration and prescribed dose, and concomitant drugs. Of 87 patients included in the study, 41 were prescribed an enzyme-inducing antiseizure drug. Although perampanel dosage did not differ between patients prescribed/not prescribed enzyme-inducing antiseizure drugs, serum concentrations were significantly lower in patients taking enzyme-inducing antiseizure drugs (average serum concentration for the enzyme-inducing antiseizure drug group was still above the previously reported efficacious serum concentration of 70 ng/mL). Although perampanel serum concentrations are negatively influenced by enzyme-inducing antiseizure drugs in children, it is likely that efficacy would be improved in patients not concomitantly prescribed enzyme-inducing antiseizure drugs because pediatric perampanel dosing is similar to that reported in prior adult efficacy trials
%K epilepsy
%K perampanel
%K enzyme-inducing
%K antiepileptic drugs
%K pediatric
%K serum concentrations
%U https://journals.sagepub.com/doi/full/10.1177/0883073819837465