%0 Journal Article
%T High density lipoprotein coated calcium carbonate nanoparticle for chemotherapy of breast cancer
%A Jiaming Zhang
%A Kai Wei
%A Peng Fu
%A Pengfei Shi
%A Xun Li
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328219850759
%X Satisfactory chemotherapy of breast cancer remains to be a great challenge in both experimental and clinical practice. Here in our study, we successfully developed a mixed drug delivery system composed of high density lipoprotein and calcium carbonate nanoparticles. The well-defined calcium carbonate nanoparticles served as a skeleton material to load anticancer drug doxorubicin, while high density lipoprotein served as a coating material to increase the stability and biocompatibility of the as-prepared mixed drug delivery system. Our experimental results indicated that the doxorubicin loading efficiency of HDL/CC nanoparticles was relatively high that is beneficial for the following administration. On the other hand, drug loaded HDL/CC/DOX nanoparticles can increase the uptake ratio of doxorubicin into breast cancer cells (MCF-7) compared with bare CC/DOX nanoparticles. Moreover, the in vivo tumor homing ability of HDL/CC nanoparticles as also superior than bare CC/DOX nanoparticles. Thus, HDL/CC/DOX nanoparticles exhibited stronger anticancer activity in vitro than free DOX or CC/DOX nanoparticles with minimized toxic side effects and preferable tumor-suppression capability on tumor-bearing nude mice model, which holds the potential to be further developed as a promising drug delivery system to be administered in clinic
%K High density lipoprotein
%K calcium carbonate
%K chemotherapy
%K doxorubicin
%K breast cancer
%U https://journals.sagepub.com/doi/full/10.1177/0885328219850759