%0 Journal Article
%T Ageing influences the relationship of circulating miR
%A Fernanda-Isadora Corona-Meraz
%A Francisco Jos¨¦ Ortega
%A Milton-Omar Guzm¨¢n-Ornelas
%A M¨®nica V¨¢zquez-Del Mercado
%A Rosa-Elena Navarro-Hern¨¢ndez
%A Sandra-Luz Ruiz-Quezada
%J Diabetes and Vascular Disease Research
%@ 1752-8984
%D 2019
%R 10.1177/1479164118816659
%X The identification of circulating microRNAs related to abnormal metabolic function may be useful in the context of ageing, adiposity and insulin resistance. The miR-33a/b has been shown to control the expression of genes involved in fatty acid biosynthesis, impaired metabolism and insulin resistance. In this study, we aimed to identify differences in circulating miR-33a/b levels according to age-related metabolic impairment and increased adiposity. This study included 80 individuals (30.2% with obesity, 70% females) classified according to insulin resistance (Stern¡¯s criteria) and age [young (20¨C39£¿years) and senior (40¨C59£¿years)]. Body fat was evaluated using bioelectrical impedance, biochemical markers by colorimetric, enzymatic and immuno-turbidimetry methods. TaqMan measures of circulating miR-33a and miR-33b with quantitative reverse transcription polymerase chain reaction in serum were assessed in association with clinical outputs. Circulating miR-33a and miR-33b levels showed significant association with fatness, the lipid profile and biomarkers of impaired glucose metabolism. Both miR-33a and miR-33b were associated with visceral adiposity index in non-insulin resistance and insulin resistance individuals. More important, for miR-33a circulating levels in senior group, receiver operating characteristic curve analyses showed area under the curve 0.804 (p£¿=£¿0.010; 95% confidence interval£¿=£¿0.655¨C0.952). Ageing influenced the relationship of circulating miR-33a and miR-33b with insulin resistance and increased adiposity
%K Insulin resistance
%K microRNAs
%K miR-33
%K ageing
%K body adiposity
%K metabolic markers
%U https://journals.sagepub.com/doi/full/10.1177/1479164118816659