%0 Journal Article
%T Frailty as an instrument for evaluation of elderly patients with non
%A David Andersson
%A Eva Swahn
%A Joakim Alfredsson
%A Karen Alexander
%A Magnus Janzon
%A Marcus Lindenberger
%A Niklas Ekerstad
%A Sofia Eriksson
%A Staffan Pettersson
%J European Journal of Preventive Cardiology
%@ 2047-4881
%D 2018
%R 10.1177/2047487318799438
%X There is a growing body of evidence on the relevance of using frailty measures also in a cardiovascular context. The estimated time to death is crucial in clinical decision-making in cardiology. However, data on the importance of frailty in long-term mortality are very scarce. The aim of the study was to assess the prognostic value of frailty on mortality at long-term follow-up of more than 5 years in patients 75 years or older hospitalised for non-ST-segment elevation myocardial infarction. We hypothesised that frailty is independently associated with long-term mortality. This was a prospective, observational study conducted at three centres. Frailty was assessed according to the Canadian Study of Health and Aging clinical frailty scale (CFS). Of 307 patients, 149 (48.5%) were considered frail according to the study instrument (degree 5¨C7 on the scale). The long-term all-cause mortality of more than 5 years (median 6.7 years) was significantly higher among frail patients (128, 85.9%) than non-frail patients (85, 53.8%), (P£¿<£¿0.001). In Cox regression analysis, frailty was independently associated with mortality from the index hospital admission to the end of follow-up (hazard ratio 2.06, 95% confidence interval 1.51¨C2.81; P£¿<£¿0.001) together with age (P£¿<£¿0.001), ejection fraction (P£¿=£¿0.012) and Charlson comorbidity index (P£¿=£¿0.018). In elderly non-ST-segment elevation myocardial infarction patients, frailty was independently associated with all-cause mortality at long-term follow-up of more than 6 years. The combined use of frailty and comorbidity may be the ultimate risk prediction concept in the context of cardiovascular patients with complex needs
%K Elderly
%K frailty
%K NSTEMI
%K long-term mortality
%U https://journals.sagepub.com/doi/full/10.1177/2047487318799438