%0 Journal Article
%T Human Semen Quality, Sperm DNA Damage, and the Level of Urinary Concentrations of 1N and TCPY, the Biomarkers of Nonpersistent Insecticides
%A Anna Klimowska
%A Bartosz Wielgomas
%A Emila Dziewirska
%A Joanna Jurewicz
%A Maciej S£¿odki
%A Micha£¿ Radwan
%A Pawe£¿ Ka£¿u£¿ny
%A Pawe£¿ Radwan
%A Wojciech Hanke
%J American Journal of Men's Health
%@ 1557-9891
%D 2019
%R 10.1177/1557988318816598
%X The aim of the study was to evaluate the association between environmental exposure to nonpersistent insecticides and semen quality (concentration, motility, morphology, computer-aided semen analysis [CASA] parameters, and sperm DNA damage). Urine samples (n = 315) collected from men who attended the infertility clinic with normal semen concentration of 15 to 300 mln/ml and age under 45 years were analyzed for two metabolites (1-naphthol [1N] and 3,5,6-trichloro-2-pyridinol [TCPY]) of nonpersistent insecticides. Participants provided semen, blood, and saliva samples; additionally, men filled a detailed questionnaire. The results identified that urinary TCPY concentration was significantly associated with a decrease in motility; also there was a positive association between TCPY and DNA fragmentation index (DFI). 1N concentration was negatively associated with a percentage of sperm with normal morphology and positively with one of the CASA parameters (curvilinear velocity [VCL]). The results suggest that environmental exposure to nonpersistent insecticides may have an impact on semen quality parameters and sperm DNA damage
%K semen quality
%K DNA damage
%K carbaryl
%K chlorpyrifos
%U https://journals.sagepub.com/doi/full/10.1177/1557988318816598