%0 Journal Article
%T Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer¡¯s disease
%A Alexander Drzezga
%A Christian Sorg
%A Christine Preibisch
%A Claus Zimmer
%A Ebba Beller
%A Igor Yakushev
%A Isabelle Riederer
%A Jens G£¿ttler
%A Karl Peter Bohn
%A Lorenzo Pasquini
%A Panagiotis Alexopoulos
%A Stephan Kaczmarz
%A Timo Grimmer
%J Journal of Cerebral Blood Flow & Metabolism
%@ 1559-7016
%D 2019
%R 10.1177/0271678X18759182
%X Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer¡¯s disease (AD), and suggested to reflect reduced coherence in neural population activity; however, as both neuronal and vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute to reduced BOLD-FC; 42 AD patients and 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed BOLD co-activity to quantify BOLD-FC, pulsed arterial spin labeling (pASL) assessed cerebral blood flow (CBF) as proxy for vascular hemodynamics, and 18F-fluorodeoxyglucose PET assessed glucose metabolism (GluMet) to index neuronal activity. Patients¡¯ BOLD-FC, CBF, and GluMet were reduced within the same precuneal parietal regions. BOLD-FC was positively associated with mean CBF, specifically in patients and controlled for GluMet levels, suggesting that BOLD-FC reductions correlate with pASL-derived hypoperfusion in AD, independently from 18F-fluorodeoxyglucose PET-derived hypometabolism. Data indicate that impaired vascular hemodynamic processes contribute to reduced BOLD connectivity in AD
%K Alzheimer¡¯s disease
%K resting-state fMRI
%K blood oxygenation level dependent-functional connectivity
%K arterial spin labeling
%K 18F-fluorodeoxyglucose-positron emission tomography
%U https://journals.sagepub.com/doi/full/10.1177/0271678X18759182