%0 Journal Article
%T Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease
%A Candy Gijsen
%A Daisy J A Janssen
%A Emiel F M Wouters
%A Fiona A H M Cleutjens
%A Frits M E Franssen
%A Jeanette B Dijkstra
%A Lowie E G W Vanfleteren
%A Martijn A Spruit
%A Rudolf W H M Ponds
%J Chronic Respiratory Disease
%@ 1479-9731
%D 2018
%R 10.1177/1479972317709651
%X We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George¡¯s Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183 COPD patients (mean age 63.6 (9.4) years, FEV1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1¨C4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and GOLD groups A¨CD (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV1% predicted, mMRC, 6MWT, COPM, CAT, HADS, BDI, and SCL-90 scores. Clinical characteristics of COPD patients with and without CI are comparable. Assessment of CI in COPD, thus, requires an active case-finding approach
%K COPD
%K cognitive impairment
%K functional status
%K health status
%K psychological well-being
%K pulmonary rehabilitation
%U https://journals.sagepub.com/doi/full/10.1177/1479972317709651