%0 Journal Article
%T The efficacy comparison of citalopram, fluoxetine, and placebo on motor recovery after ischemic stroke: a double
%A Ehsan Karimialavijeh
%A Mahtab Ramezani
%A Marjan Asadollahi
%A Ziba Khanmoradi
%J Clinical Rehabilitation
%@ 1477-0873
%D 2018
%R 10.1177/0269215518777791
%X The present study aimed to assess the effectiveness of oral citalopram, compared with fluoxetine and a placebo, in patients with post-stroke motor disabilities. A randomized double-blind placebo-controlled clinical trial was conducted between January 2015 and January 2016. The neurology department of a university-affiliated urban hospital in Tehran, Iran. Ninety adult patients with acute ischemic stroke, hemiplegia, or hemiparesis and a Fugl-Meyer Motor Scale score of below 55 were included. Participants were randomly allocated to one of three groups: Group A received 20£¿mg PO of fluoxetine daily, Group B received 20£¿mg PO of citalopram daily, and Group C received a placebo PO The duration of the therapy was 90£¿days. In addition to the medications, all of the participants received physiotherapy. Functional status at 90£¿days, which was measured by the Fugl-Meyer Motor Scale score. The initial mean (SD) Fugl-Meyer Motor Scale scores for the placebo, fluoxetine, and citalopram groups were 18.2 (11.42), 20.08 (14.53), and 17.07 (14.92), respectively. After 90£¿days, the scores were 27.96 (18.71) for the placebo group, 52.42 (26.24) for the fluoxetine group, and 50.89 (27.17) for the citalopram group. Compared with the placebo group, the mean Fugl-Meyer Motor Scale scores showed significant increases in the fluoxetine and citalopram groups (P£¿=£¿0.001). There was no significant difference between citalopram and fluoxetine in facilitating post-stroke motor recovery in ischemic stroke patients. However, compared with a placebo, both drugs improved post-stroke motor function
%K Ischemic stroke
%K motor function
%K fluoxetine
%K citalopram
%K placebo controlled
%U https://journals.sagepub.com/doi/full/10.1177/0269215518777791