%0 Journal Article
%T Identification of CD37, cystatin A, and IL
%A Ammoren Dohm
%A Boris Pasche
%A Christina Bellinger
%A Emory R. McTyre
%A Fei Xing
%A Hui-Wen Lo
%A James M. Taylor
%A Jimmy Ruiz
%A Jing Su
%A Kounosuke Watabe
%A Lance D. Miller
%A Linda J. Metheny-Barlow
%A Michael D. Chan
%A Stacey O¡¯Neill
%A Travis Dotson
%A W. Jeffrey Petty
%J The International Journal of Biological Markers
%@ 1724-6008
%D 2019
%R 10.1177/1724600818803104
%X We aimed to assess the predictive value of a lung cancer gene panel for the development of brain metastases. Between 2011 and 2015, 102 patients with lung cancer were prospectively enrolled in a clinical trial in which a diagnostic fine-needle aspirate was obtained. Gene expression was conducted on all samples that rendered a diagnosis of non-small cell lung cancer (NSCLC). Subsequent retrospective analysis of brain metastases-related outcomes was performed by reviewing patient electronic medical records. A competing risk multivariable regression was performed to estimate the adjusted hazard ratio for the development of brain metastases and non-brain metastases from NSCLC. A total of 49 of 102 patients had died by the last follow-up. Median time of follow-up was 13 months (range 0.23¨C67 months). A total of 17 patients developed brain metastases. Median survival time after diagnosis of brain metastases was 3.58 months (95% confidence interval (CI) 2.17, not available). A total of 30 patients developed metastases without any evidence of brain metastases until the time of death or last follow-up. Competing risk analysis identified three genes that were downregulated differentially in the patients with brain metastases versus non-brain metastatic disease: CD37 (0.017), cystatin A (0.022), and IL-23A (0.027). Other factors associated with brain metastases include: stage T (P £¿ 8.3e-6) and stage N (P= 6.8e-4). We have identified three genes, CD37, cystatin A, and IL-23A, for which downregulation of gene expression was associated with a greater propensity for developing brain metastases. Validation of these biomarkers could have implications on surveillance patterns in patients with brain metastases from NSCLC
%K Lung cancer
%K brain metastases
%K non-small cell lung cancer
%K gene expression
%K survival
%U https://journals.sagepub.com/doi/full/10.1177/1724600818803104