%0 Journal Article
%T Non
%A Angel Chamorro
%A Eric Vicaut
%A Heinrich P Mattle
%A Ian Ford
%A Julien Labreuche
%A Kim M Fox
%A Leila Sissani
%A Marc Fisher
%A Marie-Germaine Bousser
%A Michael G Hennerici
%A Peter M Rothwell
%A Philippe Gabriel Steg
%A Pierre Amarenco
%A Takao Hoshino
%J European Stroke Journal
%@ 2396-9881
%D 2019
%R 10.1177/2396987318797245
%X We aimed to compare the characteristics and vascular outcomes between Asian and non-Asian patients with non-cardioembolic stroke/transient ischaemic attack receiving antiplatelet monotherapy and to identify population-specific predictors for recurrent events. We conducted a post-hoc analysis of data from the PERFORM study, in which 19,100 patients (mean age, 67.2 years; male, 63%; 2178 Asian and 16,922 non-Asian patients) with non-cardioembolic ischaemic stroke/transient ischaemic attack were randomised to aspirin or terutroban and followed for two years. The primary outcome was a composite of major adverse cardiovascular events (non-fatal myocardial infarction, non-fatal stroke and cardiovascular death). There was no difference in major adverse cardiovascular events risk between Asian and non-Asian populations (11.1% vs. 10.5%; p£¿=£¿0.39). However, Asian patients were at significantly higher risk of intracranial haemorrhage (2.4% vs. 1.3%; hazard ratio (HR) 1.87; 95% confidence interval (CI) 1.34¨C2.60; p£¿<£¿0.001) and major bleeding (5.4% vs. 4.1%; HR 1.30; 95% CI 1.04¨C1.61; p£¿=£¿0.02). Stroke risk was significantly higher in Asian than in non-Asian populations among patients with lacunar stroke (7.4% vs. 4.5%; p£¿=£¿0.02). In multivariable analysis, diastolic blood pressure (HR per 5 mm Hg 1.08; 95% CI 1.01¨C1.16; p£¿=£¿0.03) and diabetes (HR 1.36; 95% CI 1.22¨C1.52; p£¿<£¿0.001) were independent predictors of major adverse cardiovascular events for Asian and non-Asian patients, respectively. Conclusion: Compared with non-Asian patients, Asian patients had significantly higher risk of haemorrhagic events when given antiplatelet monotherapy for secondary prevention after non-cardioembolic stroke/transient ischaemic attack. Lacunar stroke and elevated diastolic blood pressure were more associated with recurrence risk in Asian patients
%K Antiplatelet
%K bleeding
%K cerebrovascular disease
%K intracranial haemorrhage
%K race and ethnicity
%U https://journals.sagepub.com/doi/full/10.1177/2396987318797245