%0 Journal Article
%T Banxia Xiexin Decoction Is Effective to Prevent and Control Irinotecan
%A Chenghui Li
%A Fajun Xie
%A Hongyang Lu
%A Jing Qin
%A Lei Gong
%A Na Han
%J Integrative Cancer Therapies
%@ 1552-695X
%D 2018
%R 10.1177/1534735418801532
%X Background: Irinotecan (CPT-11) can be used as a first-line therapeutic drug against extensive-stage small cell lung cancer (SCLC); it can also be used in second-line treatment for SCLC. CPT-11-induced delayed diarrhea restricts its clinical application. This study aimed to confirm whether Banxia Xiexin decoction was effective in preventing and controlling CPT-11-induced delayed diarrhea. Methods: A total of 27 patients with recurrent SCLC undergoing chemotherapy regimens including CPT-11 were enrolled for the study. UGT1A1*28, UGTlAl*6, ABCB1*2, and SLCO1B1*15 gene polymorphisms were detected. If delayed diarrhea occurred in the first cycle of chemotherapy, Banxia Xiexin decoction was orally administered for 5 consecutive days starting 1 day before the second cycle of chemotherapy to prevent and control the delayed diarrhea. The objective response, overall survival, and toxicity were recorded. Results: Complete response, partial response, and stable disease were observed in none, 6, and 10 patients, respectively. Delayed diarrhea occurred in 6 patients, and 4 of 5 patients were relieved or controlled using Banxia Xiexin decoction. The median overall survival was 6 months. Conclusion: Banxia Xiexin decoction appeared to prevent and control delayed diarrhea induced by CPT-11 in this small observational study, and further study with a larger sample size, including potentially randomized trials, is suggested
%K Banxia Xiexin decoction
%K delayed diarrhea
%K irinotecan
%K chemotherapy
%K small cell lung cancer
%U https://journals.sagepub.com/doi/full/10.1177/1534735418801532