%0 Journal Article
%T Synthesis of zwitterionic acrylamide copolymers for biocompatible applications
%A Huanhuan Ren
%A Jinlian Hu
%A Shaojun Chen
%A Yangyang Chen
%A Zaochuan Ge
%A Zhankui Mei
%J Journal of Bioactive and Compatible Polymers
%@ 1530-8030
%D 2018
%R 10.1177/0883911517707776
%X In order to prepare acrylamide copolymers with non-toxicity for environment-friendly materials, a series of zwitterionic acrylamide copolymers with varying acrylamide content were synthesized with DMAPS (3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) and acrylamide via free radical polymerization. The structural properties and cytotoxicity are carefully investigated. The results demonstrate that DMAPS-co-acrylamide copolymers contain DMAPS and acrylamide segments that form a matrix consisting of strong electrostatic interactions as well as strong hydrogen bonding. DMAPS segments exhibit negligible influence on the glass phase transition behavior, yet affect the composite¡¯s water-contact angle. The optimum hydrophilic properties are obtained by adjusting the acrylamide content to 50 wt%. All DMAPS-co-acrylamide copolymers are measured to be non-toxic. The DMAPS segments allow for suitable contribution to the biocompatibility of the synthesized copolymer, in which copolymers containing higher DMAPS content demonstrate better biocompatibility
%K Zwitterionic polymer
%K acrylamide
%K biocompatibility
%K non-toxicity
%K electrostatic
%U https://journals.sagepub.com/doi/full/10.1177/0883911517707776