%0 Journal Article
%T Combined Tongue
%A Alexa Robbins
%A Larry D. Hartzell
%A Yuri A. Zarate
%J The Cleft Palate
%@ 1545-1569
%D 2019
%R 10.1177/1055665618773192
%X This report describes the presentation of a newborn male with circumferential tongue-palate fusion associated with cleft palate and alveolar bands. After intraoral adhesions lysis, the patient was diagnosed with Pierre Robin sequence. A family history of cleft lip and palate was noted, and interferon regulatory factor 6 (IRF6) sequencing revealed a heterozygous variant, confirming the diagnosis of van der Woude syndrome. The disruption of IRF6 resulted in abnormal orofacial development including micrognathia and intraoral adhesions as well as tongue-palate fusion, then resulting in glossoptosis with airway obstruction and cleft palate
%K tongue-palate fusion
%K van der Woude syndrome
%K IRF6
%K Pierre Robin sequence
%K cleft
%U https://journals.sagepub.com/doi/full/10.1177/1055665618773192