%0 Journal Article
%T Negative
%A Honghui Su
%A Jianda Zhou
%A Ke Cao
%A Ningning Tang
%A Shaohua Wang
%A Sijie Tang
%A Yu Liu
%J The International Journal of Lower Extremity Wounds
%@ 1552-6941
%D 2018
%R 10.1177/1534734618794856
%X Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in the treatment of various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role of the microRNA-mediated regulation of angiogenesis in ischemic tissues, and a series of microRNAs associated with angiogenesis have been successively identified. In this study, we found that miR-195 expression was significantly upregulated and the microvessel density (MVD) was increased in granulation tissue collected 7 days after NPWT compared with those in the pre-NPWT tissue. Moreover, the expression of NLRX1, the potential target gene of miR-195, was down-regulated in post-NPWT compared with that in pre-NPWT tissue. Significant negative correlations were detected between miR-195 and NLRX1 expression levels (r = £¿.856, P < .001) and between NLRX1 expression and MVD (r = £¿.618, P < .05), whereas miR-195 expression was positively correlated with MVD in the granulation tissue (r = .630, P < .05). In summary, NPWT may suppress NLRX1 expression through the upregulation of miR-195 expression, thus efficaciously promoting angiogenesis in the granulation tissue to enhance wound healing
%K negative-pressure wound therapy
%K microRNA-195
%K NLRX1
%K angiogenesis
%U https://journals.sagepub.com/doi/full/10.1177/1534734618794856