%0 Journal Article
%T Biologic Agents for the Treatment of Chronic Rhinosinusitis With Nasal Polyps
%A Alison G. Kartush
%A Jane K. Schumacher
%A Monica O. Patadia
%A Rachna Shah
%J American Journal of Rhinology & Allergy
%@ 1945-8932
%D 2019
%R 10.1177/1945892418814768
%X Chronic rhinosinusitis with nasal polyposis is a complex inflammatory disorder, which is often recalcitrant to medical and surgical management. Recently, biologic agents have been studied as an adjunct treatment for this patient population. The purpose of this study is to examine the role of biologic agents for chronic rhinosinusitis patients by reviewing literature and clinical trials. A comprehensive review of literature and clinical trials¡ªboth recently completed and ongoing¡ªwas undertaken to examine up-to-date evidence of current biologic therapy and its role in chronic rhinosinusitis patients¡ªincluding anti-IgE, anti-IL-4, anti-IL-5, anti-IL-13, and GATA-3 DNAzyme. Specific biologic agents discussed include omalizumab, reslizumab, mepolizumab, benralizumab, dupilumab, and Hgd40/SB010. Risks, side effects, and administration information are also reviewed. An algorithm for the use of biologics in patients with chronic rhinosinusitis with nasal polyposis is proposed. These treatments have promising results and may prove to be an important adjunct for patients with recalcitrant sinus disease
%K chronic rhinosinusitis
%K nasal polyposis
%K biologic agents
%K anti-IgE
%K anti-IL-4
%K anti-IL-5
%K anti-IL-13
%K GATA-3 DNAzyme
%K omalizumab
%K reslizumab
%K mepolizumab
%K benralizumab
%K dupilumab
%K Hgd40
%K SB010
%U https://journals.sagepub.com/doi/full/10.1177/1945892418814768