%0 Journal Article
%T Copper nanoparticles stabilized with cashew gum: Antimicrobial activity and cytotoxicity against 4T1 mouse mammary tumor cell line
%A Adriany Amorim
%A Alexandra Pl¨¢cido
%A Alyne Rodrigues de Ara¨²jo
%A Ana Carolina Mafud
%A Beatriz L¨®pez-Ruiz
%A Cristina Delerue-Matos
%A Daniel Dias Rufino Arcanjo
%A Durcilene Silva
%A Fernando A¨¦cio Amorim Carvalho
%A Joilson Ramos- Jesus
%A Jos¨¦ Roberto Souza Almeida Leite
%A Maria Brito Neta
%A Marta S¨¢nchez-Paniagua L¨®pez
%A Michel Mu¨¢lem Moraes Alves
%A Peter Eaton
%A Sacha Braun
%A Silvania Nogueira
%A Yvonne Mascarenhas
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328219845964
%X Copper nanoparticles stabilized with cashew (CG-CuNPs) were synthesized by reduction reaction using ascorbic acid and sodium borohydride, using the cashew gum (CG) as a natural polymer stabilizer. Dynamic light scattering, atomic force microscopy, Fourier-transform infrared spectroscopy, UV-Vis spectrophotometry, and x-ray diffraction were used to characterize the nanoparticles (CG-CuNPs), and copper was quantified by electrochemical measurement. The UV-vis spectra of the CG-CuNPs confirmed the formation of nanoparticles by appearance of a surface plasmon band at 580 nm after 24 h of reaction. The Fourier-transform infrared spectrum of CG-CuNPs showed the peak at 1704 cm£¿1 from cashew gum, confirming the presence of the gum in the nanoparticles. The average size of CG-CuNPs by dynamic light scattering and atomic force microscopy was around 10 nm, indicating small, approximately spherical particles. Antimicrobial assays showed that CG-CuNPs had activity against Staphylococcus aureus ATCC 29213 with a minimal inhibitory concentration of 0.64 mM. The cytotoxicity assay on BALB/c murine macrophages showed lower cytotoxic effects for CG-CuNPs than CuSO4¡¤5H2O. Viability cell assays for CG-CuNPs at (0.250 mM) inhibited by 70% the growth of 4T1 LUC (4T1 mouse mammary tumor cell line) and NIH 3T3 cells (murine fibroblast cells) over a 24-h period. Therefore, CG-CuNPs can be used as an antimicrobial agent with lower cytotoxic effects than the CuSO4¡¤5H2O precursor
%K Copper nanoparticles
%K cashew gum
%K cancer
%K antimicrobial
%U https://journals.sagepub.com/doi/full/10.1177/0885328219845964