%0 Journal Article
%T Comparison between intra
%A Andr谷 Rosenfeld
%A Jamil Natour
%A Jamille Godoy Mendes
%A Jos谷 Carlos Nunes-Tamashiro
%A Rita Nely Vilar Furtado
%A Sandra Regina Toffolo
%J Clinical Rehabilitation
%@ 1477-0873
%D 2019
%R 10.1177/0269215519827996
%X To compare the effectiveness of intra-articular injection (IAI) with Botulinum toxin type A (BTA), triamcinolone hexacetonide (TH), and saline in primary knee osteoarthritis. A randomized controlled trial, with blinded patients and assessor. Outpatient rheumatology service. Patients with knee osteoarthritis grades II and III. Patients received IAI with 100ˋIU BTA, 40ˋmg TH, or isotonic saline solution (SS) 0.9%. Patients were assessed at baseline and at 4, 8, and 12ˋweeks with the following instruments: visual analog scale for pain during movement (VASm; primary outcome) and visual analog scale for pain at rest (VASr), Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, 6-minute walk test, Timed Up and Go test, Short Form (SF)-36 questionnaire, range of motion of knee, and ultrasound (US) measurement of synovial hypertrophy. In total, 105 patients were randomized, with 35 in each group; 96 were female (91.4%) and 9 were male (8.6%), with a mean age of 64.2ˋyears (㊣6.9). At 12ˋweeks, the TH group showed better results only for VASm. At four weeks, the TH group showed better results than the BTA and SS groups for VASm (每68.9% (37.8) vs. 每35.3% (40.3) vs. 每35.9% (51.4)), WOMAC pain (每56.0% (30.7) vs. 每30.8% (34.3) vs. 每30.0% (39.9)), WOMAC stiffness (每53.4% (38.4) vs. 每17.2% (59.3) vs. 每17.3% (78.1)), WOMAC function (每48.2% (34.6) vs. 30.8% (33.6) vs. 每13.6% (64.9)), WOMAC total score (每51.2% (31.0) vs. 每30.9% (30.0) vs. 每18.8% (54.8)), and US measurement of synovial hypertrophy (每11.6% (44.9) vs. 每1.5% (47.9) vs. +28.6% (81.3)). IAI with TH had a higher effectiveness than that with TBA or SS in the short-term assessment (four weeks) for pain in movement, WOMAC, and US measurement of synovial hypertrophy
%K Osteoarthritis of the knee
%K intra-articular
%K Botulinum toxin type A
%K corticosteroid
%U https://journals.sagepub.com/doi/full/10.1177/0269215519827996