%0 Journal Article
%T Prussian blue
%A Hao Li
%A Jin-Hai Tang
%A Li Ding
%A Wei Zhang
%A Xing-Wang Li
%A Yang Wu
%J Journal of Biomaterials Applications
%@ 1530-8022
%D 2019
%R 10.1177/0885328218825175
%X To realize the photothermal therapy ability of Prussian blue-modified ferritin nanoparticles (PB-Ft NPs) and its synergistic effect with chemotherapy, PB-Ft NPs were synthesized by a simple surface double decomposition reaction. Mean sizes of ferritin and PB-Ft NPs were 10.4 nm and 12.6 nm, respectively. The obtained PB-Ft NPs were verified to have both the photothermal conversion ability of Prussian blue and the morphology of ferritin. The in vitro and in vivo photothermal therapy results confirm PB-Ft NPs can successfully inhibit the growth of murine breast cancer cell line (4T1) without any obvious side effect. Moreover, taking use of the peroxidase-like activity of PB-Ft NPs, the photothermal therapy effect of PB-Ft NPs effectively improved the curative effect of gemcitabine (GEM) via enhancing reactive oxygen species production. The obtained PB-Ft NPs can be served as a useful and safe photothermal therapy agent in breast cancer. Moreover, PB-Ft NPs-assisted photothermal therapy can be applied as an adjunctive therapy with various established cancer treatments such as chemotherapy
%K Prussian blue
%K photothermal therapy
%K ferritin
%K gemcitabine
%K reactive oxygen species
%K adjunctive therapy
%U https://journals.sagepub.com/doi/full/10.1177/0885328218825175