%0 Journal Article
%T Serum 8
%A Chongbin Tian
%A Fang Zhao
%A Fengling Zhao
%A Jianpo Wang
%A Jie Li
%A Lin Han
%A Ping Wang
%A Qiao Zhang
%A Yu Gao
%A Yumin Lyu
%A Zhaonan Wang
%J Dose
%@ 1559-3258
%D 2019
%R 10.1177/1559325818820649
%X In this study, the effect of ionizing radiation on 8-hydroxy-2¡ä-deoxyguanosine (8-OHdG) in human peripheral blood was investigated. Blood samples were collected from 230 radiation workers and 8 patients who underwent radiotherapy for population study. Blood samples from 2 healthy individuals were irradiated with different X-ray doses for in vitro experiment, and levels of 8-OHdG in serum and cell culture supernatants were assessed by enzyme-linked immunosorbent assay. Observations demonstrated the positive relationships between serum 8-OHdG level and radiation dose and working period were observed, and serum 8-OHdG levels were higher among interventional radiation workers than among other hospital radiation workers. In addition, 8-OHdG yields in supernatants increased, peaked at 3 Gy of radiation dose, and then decreased with further increases in radiation; the dose¨Cresponse curve obtained fitted a polynomial function. By contrast, a similar trend was not found in radiotherapy patients. The present study suggests that 8-OHdG may be a useful biomarker reflecting oxidative damage among workers occupationally exposed to low-dose radiation
%K ionizing radiation
%K radiation workers
%K radiotherapy patients
%K in vitro irradiation
%K human peripheral blood
%K 8-hydroxy-2¡ä-deoxyguanosine
%U https://journals.sagepub.com/doi/full/10.1177/1559325818820649