%0 Journal Article %T Blunted cerebrovascular response is associated with elevated beta %A Eric D Vidoni %A Jaimie Ward %A Jason-Flor V Sisante %A Jeffrey M Burns %A Kiersten Kirkendoll %A Rebecca Maletsky %A Sandra A Billinger %A Sarah Kwapiszeski %A Yumei Liu %J Journal of Cerebral Blood Flow & Metabolism %@ 1559-7016 %D 2019 %R 10.1177/0271678X17732449 %X The goal of this study was to explore the association of beta-amyloid accumulation and cerebrovascular response (CVR) in cognitively normal older adults. Beta-amyloid accumulation was characterized with [18F] Florbetapir positron emission tomography scans. CVR was calculated as middle cerebral artery blood flow velocity change from rest to moderate intensity exercise. We found that individuals with elevated beta-amyloid aggregation had a blunted CVR (n£¿=£¿25, age 70.1£¿¡À£¿4.8; 3.3£¿¡À£¿3.7£¿cm/s) compared to non-elevated individuals (n£¿=£¿45, age 72.0£¿¡À£¿4.9; 7.2£¿¡À£¿5.0£¿cm/s, p£¿<£¿0.001). Further, greater beta-amyloid burden was linearly associated with less CVR across all participants (b£¿=£¿£¿11.7, p£¿<£¿0.001). Greater CVR and less beta-amyloid burden were associated with processing speed (p£¿<£¿0.05). This study is the first to show that CVR from rest to exercise is blunted across increased global beta-amyloid burden %K Alzheimer's disease %K cerebrovascular %K cognitive aging %K vascular dementia %K ultrasound %U https://journals.sagepub.com/doi/full/10.1177/0271678X17732449