%0 Journal Article
%T Blunted cerebrovascular response is associated with elevated beta
%A Eric D Vidoni
%A Jaimie Ward
%A Jason-Flor V Sisante
%A Jeffrey M Burns
%A Kiersten Kirkendoll
%A Rebecca Maletsky
%A Sandra A Billinger
%A Sarah Kwapiszeski
%A Yumei Liu
%J Journal of Cerebral Blood Flow & Metabolism
%@ 1559-7016
%D 2019
%R 10.1177/0271678X17732449
%X The goal of this study was to explore the association of beta-amyloid accumulation and cerebrovascular response (CVR) in cognitively normal older adults. Beta-amyloid accumulation was characterized with [18F] Florbetapir positron emission tomography scans. CVR was calculated as middle cerebral artery blood flow velocity change from rest to moderate intensity exercise. We found that individuals with elevated beta-amyloid aggregation had a blunted CVR (n£¿=£¿25, age 70.1£¿¡À£¿4.8; 3.3£¿¡À£¿3.7£¿cm/s) compared to non-elevated individuals (n£¿=£¿45, age 72.0£¿¡À£¿4.9; 7.2£¿¡À£¿5.0£¿cm/s, p£¿<£¿0.001). Further, greater beta-amyloid burden was linearly associated with less CVR across all participants (b£¿=£¿£¿11.7, p£¿<£¿0.001). Greater CVR and less beta-amyloid burden were associated with processing speed (p£¿<£¿0.05). This study is the first to show that CVR from rest to exercise is blunted across increased global beta-amyloid burden
%K Alzheimer's disease
%K cerebrovascular
%K cognitive aging
%K vascular dementia
%K ultrasound
%U https://journals.sagepub.com/doi/full/10.1177/0271678X17732449